Genes differentially regulated by HO-1 were enriched for cell motility and adhesion biological processes. Here, we investigated whether HO-1 is implicated in the adhesive and morphological properties of tumor cells.
Heme oxygenase-1 (HO-1) counteracts oxidative and inflammatory damage.
Inflammation and the involvement of reactive oxygen species (ROS) are critical in the regulation of cell adhesion and the integrity of the epithelium. Although previous studies in PCa have focused on cell adherens junctions (AJs), key players in metastasis, they have left the molecular mechanisms unexplored. Prostate cancer (PCa) is the second leading cause of cancer death in men. Received: JanuAccepted: MaPublished: March 16, 2014 Keywords: Prostate Cancer, Heme-oxygenase-1, Muskelin, E-cadherin, B-catenin, Adherens Junctions, Geraldine Gueron 1, Jimena Giudice 2, Pia Valacco 3, Alejandra Paez 1, Belen Elguero 1, Martin Toscani 1, Felipe Jaworski 1, Federico Coluccio Leskow 1, Javier Cotignola 1, Marcelo Marti 1, Maria Binaghi 1, Nora Navone 4, Elba Vazquez 1ġ Department of Biological Chemistry, School of Sciences, University of Buenos Aires, IQUIBICEN-CONICET, Intendente Guiraldes 2160, CABAĢ Department of Pathology and Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USAģ CEQUIBIEM-Department of Biological Chemistry, School of Sciences, University of Buenos Aires, IQUIBICEN-CONICETĤ Department of Genitourinary Medical Oncology, The University of Texas, M.
0 kommentar(er)
